2677762-43-3

2677762-43-3 structure

2677762-43-3 structure

Name: HIV-1 inhibitor-45
Chemical Name: HIV-1 inhibitor-45
CAS Number: 2677762-43-3
Molecular Formula: C₂₃H₂₄N₄O₈S
Molecular Weight: 516.52
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-09-15 12:26:52
Modify Date: 2024-04-03 20:29:17
HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].

Name	HIV-1 inhibitor-45

Description	HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 0.067 μM (HIV-1 RNase H)[1]
In Vitro	HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1]. HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].
References	[1]. Zhang L, et, al. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem. 2022 Jun 26;240:114563.

Molecular Formula	C₂₃H₂₄N₄O₈S
Molecular Weight	516.52