HIV-1 inhibitor-55

Modify Date: 2024-04-03 17:09:34

HIV-1 inhibitor-55 Structure
HIV-1 inhibitor-55 structure
Common Name HIV-1 inhibitor-55
CAS Number 2771211-73-3 Molecular Weight 548.66
Density N/A Boiling Point N/A
Molecular Formula C28H32N6O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-55


HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC50 value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection[1].

 Names

Name HIV-1 inhibitor-55

 HIV-1 inhibitor-55 Biological Activity

Description HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC50 value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection[1].
Related Catalog
In Vitro HIV-1 inhibitor-55 对野生型 HIV-1 表现出抑制作用,EC50 值为 8.6 nM[1]。 HIV-1 inhibitor-55 对 HIV-1 突变体 L100I,K103N,Y181C,Y188L,E138K 和 F227L + V106A 表现出较强的抗逆转录酶活性,其 EC50 值分别为 1.1、0.12、0.36、0.75、0.033 和 3.06 μM[1]。 HIV-1 inhibitor-55 抑制野生型 HIV-1 逆转录的活性,IC50 值为 0.11 μM[1]。
References

[1]. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.  

 Chemical & Physical Properties

Molecular Formula C28H32N6O4S
Molecular Weight 548.66