HIV-1 inhibitor 18A
Modify Date: 2025-09-26 17:49:23
HIV-1 inhibitor 18A structure
|
Common Name | HIV-1 inhibitor 18A | ||
|---|---|---|---|---|
| CAS Number | 331261-50-8 | Molecular Weight | 313.334 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H11N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 inhibitor 18AHIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding. |
| Name | (2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding. |
|---|---|
| References | References 1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52. 2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29. View Related Products by Target HIV |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H11N5O2S |
| Molecular Weight | 313.334 |
| Exact Mass | 313.063354 |
| LogP | 3.04 |
| Index of Refraction | 1.758 |
| (2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide |
| MFCD00617448 |
| Hydrazinecarboxamide, N-2,1,3-benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-, (2E)- |