HIV-1 inhibitor-43
Modify Date: 2025-09-16 06:07:41
HIV-1 inhibitor-43 structure
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Common Name | HIV-1 inhibitor-43 | ||
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| CAS Number | 2493426-43-8 | Molecular Weight | 468.95 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21ClN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 inhibitor-43HIV-1 inhibitor-43 (compound 12) is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24[1]. |
| Name | HIV-1 inhibitor-43 |
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| Description | HIV-1 inhibitor-43 (compound 12) is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24[1]. |
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| Related Catalog | |
| Target |
HIV-1 (Y188L):21.3 nM (EC50) HIV-1 (K103N+Y181C):6.2 nM (EC50) HIV-1 (K103N):<0.7 nM (EC50) HIV-1 (Y181C):<0.7 nM (EC50) |
| In Vitro | HIV-1 inhibitor-43 (compound 12) has anti-HIV-1 activity against HIV-1 reverse transcriptase with IC50s of 83±8 nM, 73±8 nM, 61±6 nM and 76±8 nM for HIV-1 WT, K103N, Y181I and K103N-Y181I, respectively[1]. HIV-1 inhibitor-43 (1, 5 and 25 nM) causes 100% reduction of HIV-1 RNA and protein p24 at 25 nM in C8166 cells infected with a WT strain[1]. |
| References |
| Molecular Formula | C24H21ClN2O4S |
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| Molecular Weight | 468.95 |