HIV-1 inhibitor-52
Modify Date: 2024-01-16 12:00:01
HIV-1 inhibitor-52 structure
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Common Name | HIV-1 inhibitor-52 | ||
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| CAS Number | 1818868-23-3 | Molecular Weight | 770.13 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C46H72FNO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 inhibitor-52HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1]. |
| Name | HIV-1 inhibitor-52 |
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| Description | HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1]. |
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| Related Catalog | |
| Target |
HIV-1 (WT):1.6 nM (EC50) HIV-1 V370A:3.0 nM (EC50) HIV-1 ΔV370:5.1 nM (EC50) HIV-1 V362I/V370A:2.0 nM (EC50) HIV-1 T332S/V362I/prR41G:6.4 nM (EC50) HIV-1 A326T/V362I/V370A:4.3 nM (EC50) HIV-1 R361K/V362I/L363M:4.5 nM (EC50) |
| In Vivo | HIV-1 inhibitor-52 (化合物 26; 1 mg/kg; 静脉给药) 在大鼠的 T1/2 为 4.2 小时，CL 为 3.5 mL/min·kg，Vss 为 0.8 L/kg[1]。 HIV-1 inhibitor-52 (5 mg/kg; 灌胃) 对大鼠的 Cmax 为 0.83 μM，AUC 为 8.11 μM·h[1]。 Animal Model: Male sprague-dawley rats[1] Dosage: 1 mg/kg Administration: IV Result: Had a T1/2 of 4.2 hours, a CL of 3.5 mL/min•kg, and a Vss of 0.8 L/kg for rats. |
| References |
| Molecular Formula | C46H72FNO5S |
|---|---|
| Molecular Weight | 770.13 |