HIV-1 inhibitor-47

Modify Date: 2025-10-30 17:07:41

HIV-1 inhibitor-47 structure	Common Name	HIV-1 inhibitor-47
	CAS Number	137448-39-6	Molecular Weight	242.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₄N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 inhibitor-47

HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].

Name	2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine
Synonym	More Synonyms

Description	HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV (Vif-dependent degradation of human APOBEC3G)[1]
In Vitro	APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication and shows antiviral activity. However HIV-1 develops the ability to hijack the cellular ubiquitin/proteasome degradation pathway[1]. HIV-1 inhibitor-47 targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), and works on the HIV-1 Vif-APOBEC3G interaction[2].
References	[1]. Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19539-44. [2]. Becker Irwin. Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45(4):1005-1022. [3]. Pubchem: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine-BioAssay Results.

Molecular Formula	C₁₂H₁₄N₆
Molecular Weight	242.28
Storage condition	2-8°C

MFCD06371724

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.