2771211-73-3

2771211-73-3 structure

Name: HIV-1 inhibitor-55
Chemical Name: HIV-1 inhibitor-55
CAS Number: 2771211-73-3
Molecular Formula: C₂₈H₃₂N₆O₄S
Molecular Weight: 548.66
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2023-04-07 01:53:02
Modify Date: 2024-04-03 17:09:34
HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC50 value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection[1].

Name	HIV-1 inhibitor-55

Description	HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with an EC50 value of 8.6 nM. HIV-1 inhibitor-55 also shows inhibitory potency against single and double HIV-1 mutants. HIV-1 inhibitor-55 can be used for the research of virus infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
In Vitro	HIV-1 inhibitor-55 对野生型 HIV-1 表现出抑制作用，EC50 值为 8.6 nM[1]。 HIV-1 inhibitor-55 对 HIV-1 突变体 L100I，K103N，Y181C，Y188L，E138K 和 F227L + V106A 表现出较强的抗逆转录酶活性，其 EC50 值分别为 1.1、0.12、0.36、0.75、0.033 和 3.06 μM[1]。 HIV-1 inhibitor-55 抑制野生型 HIV-1 逆转录的活性，IC50 值为 0.11 μM[1]。
References	[1]. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.

Molecular Formula	C₂₈H₃₂N₆O₄S
Molecular Weight	548.66