HIV-1 inhibitor-28

Modify Date: 2024-04-06 15:48:01

HIV-1 inhibitor-28 Structure
HIV-1 inhibitor-28 structure
Common Name HIV-1 inhibitor-28
CAS Number 2642218-07-1 Molecular Weight 508.64
Density N/A Boiling Point N/A
Molecular Formula C26H32N6O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-28


HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS[1].

 Names

Name HIV-1 inhibitor-28

 HIV-1 inhibitor-28 Biological Activity

Description HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS[1].
Related Catalog
Target

HIV-1 (WT):58 nM (EC50)

References

[1]. Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.

 Chemical & Physical Properties

Molecular Formula C26H32N6O3S
Molecular Weight 508.64
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