2642218-07-1

2642218-07-1 structure

Name: HIV-1 inhibitor-28
Chemical Name: HIV-1 inhibitor-28
CAS Number: 2642218-07-1
Molecular Formula: C₂₆H₃₂N₆O₃S
Molecular Weight: 508.64
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-07-19 14:53:48
Modify Date: 2025-08-26 19:48:51
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS[1].

Name	HIV-1 inhibitor-28

Description	HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	HIV-1 (WT):58 nM (EC50)
References	[1]. Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.

Molecular Formula	C₂₆H₃₂N₆O₃S
Molecular Weight	508.64