TRPA1 Antagonist 1

Modify Date: 2025-09-18 20:01:34

Use of TRPA1 Antagonist 1

TRPA1 Antagonist 1 is a methylene phosphate prodrug which converts to its active parent drug, a TRPA1 antagonist with an IC50 of 8 nM.

Name	TRPA1 Antagonist 1

Description	TRPA1 Antagonist 1 is a methylene phosphate prodrug which converts to its active parent drug, a TRPA1 antagonist with an IC50 of 8 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	IC50: 8 nM (TRPA1)[1]
References	[1]. Chen H, et al. Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. J Med Chem. 2018 Apr 26;61(8):3641-3659.

Molecular Formula	C₂₄H₂₀F₆N₅Na₂O₇PS
Molecular Weight	713.45

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