Trk-IN-3

Modify Date: 2024-01-10 19:11:04

Trk-IN-3 structure	Common Name	Trk-IN-3
	CAS Number	1873373-33-1	Molecular Weight	474.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉F₅N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Trk-IN-3

Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

Name	Trk-IN-3

Description	Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease
Target	TrkA:8.4 nM (IC50, in cell-based assays) TrkB:6.2 nM (IC50, in cell-based assays) TrkC:2.2 nM (IC50, in cell-based assays)
In Vitro	Trk-IN-3 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively[1].
References	[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.

Molecular Formula	C₂₀H₁₉F₅N₄O₄
Molecular Weight	474.38

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Trk-IN-3
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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