Trk-IN-10
Modify Date: 2024-01-09 21:37:02
Trk-IN-10 structure
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Common Name | Trk-IN-10 | ||
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| CAS Number | 2700265-61-6 | Molecular Weight | 397.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20FN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trk-IN-10Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity[1]. |
| Name | Trk-IN-10 |
|---|
| Description | Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C20H20FN5O3 |
|---|---|
| Molecular Weight | 397.40 |
| InChIKey | RZRSOLZCLWVUTL-NEPJUHHUSA-N |
| SMILES | CC1CNC(=O)c2cnn3cc4c(nc23)N(Cc2ccc(F)cc2O1)C(C)CO4 |