1873373-33-1
1873373-33-1 structure
- Name: Trk-IN-3
- Chemical Name: Trk-IN-3
- CAS Number: 1873373-33-1
- Molecular Formula: C20H19F5N4O4
- Molecular Weight: 474.38
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
- Create Date: 2019-03-03 09:35:57
- Modify Date: 2024-01-10 19:11:04
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Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
| Name | Trk-IN-3 |
|---|
| Description | Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
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| Related Catalog | |
| Target |
TrkA:8.4 nM (IC50, in cell-based assays) TrkB:6.2 nM (IC50, in cell-based assays) TrkC:2.2 nM (IC50, in cell-based assays) |
| In Vitro | Trk-IN-3 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively[1]. |
| References |
| Molecular Formula | C20H19F5N4O4 |
|---|---|
| Molecular Weight | 474.38 |
| Hazard Codes | Xi |
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