Trk-IN-4 structure
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Common Name | Trk-IN-4 | ||
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CAS Number | 1799788-94-5 | Molecular Weight | 521.46 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H23F4N5O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Trk-IN-4Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
Name | Trk-IN-4 |
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Description | Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
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Related Catalog | |
Target |
TrkA:1.9 nM (IC50, in cell-based assays) TrkB:2.6 nM (IC50, in cell-based assays) TrkC:1.1 nM (IC50, in cell-based assays) |
In Vitro | Trk-IN-4 (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1]. |
References |
Molecular Formula | C24H23F4N5O4 |
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Molecular Weight | 521.46 |
Hazard Codes | Xi |
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