DC Chemicals Limited
China
Product Name: Trk-IN-4
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1799788-94-5

1799788-94-5 structure

1799788-94-5 structure

Name: Trk-IN-4
Chemical Name: Trk-IN-4
CAS Number: 1799788-94-5
Molecular Formula: C₂₄H₂₃F₄N₅O₄
Molecular Weight: 521.46
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
Create Date: 2019-03-03 16:36:04
Modify Date: 2024-01-12 17:29:35
Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

Name	Trk-IN-4

Description	Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease
Target	TrkA:1.9 nM (IC50, in cell-based assays) TrkB:2.6 nM (IC50, in cell-based assays) TrkC:1.1 nM (IC50, in cell-based assays)
In Vitro	Trk-IN-4 (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].
References	[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.

Molecular Formula	C₂₄H₂₃F₄N₅O₄
Molecular Weight	521.46

Hazard Codes	Xi