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Trk-IN-3

Names

[ CAS No. ]:
1873373-33-1

[ Name ]:
Trk-IN-3

Biological Activity

[Description]:

Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
Research Areas >> Neurological Disease

[Target]

TrkA:8.4 nM (IC50, in cell-based assays)

TrkB:6.2 nM (IC50, in cell-based assays)

TrkC:2.2 nM (IC50, in cell-based assays)


[In Vitro]

Trk-IN-3 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively[1].

[References]

[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H19F5N4O4

[ Molecular Weight ]:
474.38

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds