2700265-62-7

2700265-62-7 structure

Name: Trk-IN-11
Chemical Name: Trk-IN-11
CAS Number: 2700265-62-7
Molecular Formula: C₂₁H₂₂FN₅O₃
Molecular Weight: 411.43
Create Date: 2022-05-14 17:23:37
Modify Date: 2024-01-10 11:20:25
Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].

Name	Trk-IN-11

Description	Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
References	[1]. Fan Y, et al. Pyrizolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2022;63:128646.

Molecular Formula	C₂₁H₂₂FN₅O₃
Molecular Weight	411.43