CCR2 antagonist 1

Modify Date: 2025-08-27 02:01:08

CCR2 antagonist 1 Structure
CCR2 antagonist 1 structure
Common Name CCR2 antagonist 1
CAS Number 1683534-96-4 Molecular Weight 549.47
Density N/A Boiling Point N/A
Molecular Formula C28H32BrF3N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CCR2 antagonist 1


CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

 Names

Name CCR2 antagonist 1

 CCR2 antagonist 1 Biological Activity

Description CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.
Related Catalog
Target

CCR2:2.4 nM (Ki)

In Vitro The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
References

[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.

 Chemical & Physical Properties

Molecular Formula C28H32BrF3N2O
Molecular Weight 549.47
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