TCS 21311
Modify Date: 2024-01-04 18:24:08
TCS 21311 structure
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Common Name | TCS 21311 | ||
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| CAS Number | 1260181-14-3 | Molecular Weight | 526.50700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H25F3N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCS 21311TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1]. |
| Name | 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione |
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| Synonym | More Synonyms |
| Description | TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1]. |
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| Related Catalog | |
| Target |
JAK3:8 nM (IC50) JAK2:2.55 μM (IC50) JAK1:1.017 μM (IC50) PKCα:13 nM (IC50) PKCθ:68 nM (IC50) GSK-3β:3 nM (IC50) |
| In Vitro | TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay[1]. TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity[1]. |
| References |
| Molecular Formula | C27H25F3N4O4 |
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| Molecular Weight | 526.50700 |
| Exact Mass | 526.18300 |
| PSA | 109.23000 |
| LogP | 3.45220 |
| NIBR-3049 |