TCS 1105

Modify Date: 2024-01-14 14:37:48

TCS 1105 structure	Common Name	TCS 1105
	CAS Number	185391-33-7	Molecular Weight	296.29600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₃FN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TCS 1105

TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].

Name	N-(4-Fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Description	TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. [2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281.

[2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812.

Molecular Formula	C₁₇H₁₃FN₂O₂
Molecular Weight	296.29600
Exact Mass	296.09600
PSA	61.96000
LogP	3.19700
Storage condition	-20°C

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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