871085-49-3

871085-49-3 structure

Name: TCS 3035
Chemical Name: [4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenoxy]acetic acid
CAS Number: 871085-49-3
Molecular Formula: C₁₂H₉NO₅S
Molecular Weight: 279.27
Catalog: Research Areas Others
Create Date: 2018-05-29 21:19:43
Modify Date: 2024-08-27 18:27:47
GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1].

Name	[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenoxy]acetic acid

Description	GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	GPR35[1]
References	[1]. Jenkins L, et al. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2. Br J Pharmacol. 2011 Feb;162(3):733-48.