TCS 46b

Modify Date: 2024-01-11 19:25:42

TCS 46b structure	Common Name	TCS 46b
	CAS Number	302799-86-6	Molecular Weight	345.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TCS 46b

TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM[1].

Name	5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one
Synonym	More Synonyms

Description	TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	IC50: 5.3 nM (NR1A/2B), 35 μM (NR1A/2A), >100 μΜ (NR1A/2C), 0.5 μM (α-1 adrenergic receptor), 2.6 μM (dopamine D2)[1]
In Vivo	TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) 在 6-OHDA 损伤大鼠中增强左旋多巴的作用[1]。 Animal Model: Sprague−Dawley rats, 6-hydroxydopamine-lesioned (6-OHDA) rat model[1] Dosage: 10 and 30 mg/kg Administration: PO or IP, once Result: Showed significant potentiation of the effects of L-DOPA in this model.
References	[1]. Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J Med Chem. 2000 Sep 7;43(18):3408-19.

Molecular Formula	C₂₂H₂₃N₃O
Molecular Weight	345.44
Exact Mass	345.18400
PSA	51.89000
LogP	3.10030
Storage condition	-20°C

tcs 46b