TCS-OX2-29
Modify Date: 2025-08-25 12:30:45
TCS-OX2-29 structure
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Common Name | TCS-OX2-29 | ||
|---|---|---|---|---|
| CAS Number | 372523-75-6 | Molecular Weight | 397.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H31N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCS-OX2-29TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1.target: OX2 IC 50: 40 nMIn vitro:TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuripeptide Y. [1]TCS-OX2-29 Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor. [2] |
| Name | TCS OX2 29 |
|---|---|
| Synonym | More Synonyms |
| Description | TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1.target: OX2 IC 50: 40 nMIn vitro:TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuripeptide Y. [1]TCS-OX2-29 Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor. [2] |
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| Related Catalog | |
| References |
| Molecular Formula | C23H31N3O3 |
|---|---|
| Molecular Weight | 397.51 |
| PSA | 63.69000 |
| LogP | 4.31880 |
| InChIKey | COFVZFLCAOUMJT-OAQYLSRUSA-N |
| SMILES | COc1cc2c(cc1OC)CN(C(=O)C(NCc1ccncc1)C(C)(C)C)CC2 |
| Storage condition | 2-8℃ |
| 8-Bromo-cGMP,sodium salt |
| (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride |
| TCS-OX2-29 |