TCS 359
Modify Date: 2024-01-04 11:40:33
TCS 359 structure
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Common Name | TCS 359 | ||
|---|---|---|---|---|
| CAS Number | 301305-73-7 | Molecular Weight | 360.427 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 454.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H20N2O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 228.6±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of TCS 359TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. IC50 Value: 42 nM [1]Target: Flt3in vitro: TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1]. |
| Name | 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide |
|---|---|
| Synonym | More Synonyms |
| Description | TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. IC50 Value: 42 nM [1]Target: Flt3in vitro: TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 454.4±45.0 °C at 760 mmHg |
| Molecular Formula | C18H20N2O4S |
| Molecular Weight | 360.427 |
| Flash Point | 228.6±28.7 °C |
| Exact Mass | 360.114380 |
| PSA | 118.89000 |
| LogP | 4.50 |
| Appearance of Characters | white to off-white |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.644 |
| Storage condition | −20°C |
| Water Solubility | H2O: <2mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
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Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
Bioorg. Med. Chem. Lett. 16 , 3282-3286 A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 mi... |
| Benzo[b]thiophene-3-carboxamide, 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro- |
| Flt-3 inhibitor |
| 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| TCS 359 |