838823-31-7

838823-31-7 structure

Name: TCS 2312
Chemical Name: [1,1'-Biphenyl]-2,4-diol, 4'-[5-[[4-[(cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]
CAS Number: 838823-31-7
Molecular Formula: C₂₅H₂₄N₄O₂
Molecular Weight: 412.48
Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
Create Date: 2016-01-11 17:37:54
Modify Date: 2024-08-26 21:17:59
CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].

Name	[1,1'-Biphenyl]-2,4-diol, 4'-[5-[[4-[(cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]
Synonyms	TCS 2312 Anpirtoline hydrochloride

Description	CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)
References	[1]. Teng M, et al. Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem. 2007 Nov 1;50(22):5253-6.