TCS 359

Names

[ Name ]:
TCS 359

[Synonym ]:
Benzo[b]thiophene-3-carboxamide, 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-
Flt-3 inhibitor
2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
TCS 359

Biological Activity

[Description]:

TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. IC50 Value: 42 nM [1]Target: Flt3in vitro: TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

Research Areas >> Cancer

[References]

[1]. Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
454.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₀N₂O₄S

[ Molecular Weight ]:
360.427

[ Flash Point ]:
228.6±28.7 °C

[ Exact Mass ]:
360.114380

[ PSA ]:
118.89000

[ LogP ]:
4.50

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: <2mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.

Bioorg. Med. Chem. Lett. 16 , 3282-3286

A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 mi...