TCS-OX2-29
Names
[ CAS No. ]:
372523-75-6
[ Name ]:
TCS-OX2-29
[Synonym ]:
8-Bromo-cGMP,sodium salt
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
TCS-OX2-29
Biological Activity
[Description]:
TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1.target: OX2 IC 50: 40 nMIn vitro:TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuripeptide Y. [1]TCS-OX2-29 Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor. [2]
[Related Catalog]:
[References]
[Related Small Molecules]
SB 334867
|
lemborexant
|
Almorexant HCI
|
Filorexant
|
Orexin 2 Receptor Agonist
|
MK-1064
|
SB-674042
|
GSK1059865
|
IPSU
|
SB408124
|
MK-3697
|
Nemorexant
|
Orexin B (mouse, rat)
|
SB-649868
|
TCS 1102
Chemical & Physical Properties
[ Molecular Formula ]:
C23H31N3O3
[ Molecular Weight ]:
397.51
[ PSA ]:
63.69000
[ LogP ]:
4.31880
[ Storage condition ]:
2-8℃