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lemborexant

Names

[ CAS No. ]:
1369764-02-2

[ Name ]:
lemborexant

[Synonym ]:
Cyclopropanecarboxamide, 2-[[(2,4-dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)-, (1R,2S)-
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide
(1R,2S)-2-{[(2,4-Dimethyl-5-pyrimidinyl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)cyclopropanecarboxamide
lemborexant

Biological Activity

[Description]:

Lemborexant (E-2006) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor)
Research Areas >> Others

[Related Small Molecules]

SB 334867 | Almorexant HCI | Filorexant | Orexin 2 Receptor Agonist | TCS-OX2-29 | MK-1064 | SB-674042 | GSK1059865 | IPSU | SB408124 | MK-3697 | Nemorexant | Orexin B (mouse, rat) | SB-649868 | TCS 1102

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
596.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H20F2N4O2

[ Molecular Weight ]:
410.417

[ Flash Point ]:
314.3±30.1 °C

[ Exact Mass ]:
410.155426

[ PSA ]:
77.00000

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.619

[ Storage condition ]:
2-8℃

Related Compounds