Neuroinflammatory-IN-3
Modify Date: 2024-01-10 00:48:50
Neuroinflammatory-IN-3 structure
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Common Name | Neuroinflammatory-IN-3 | ||
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| CAS Number | 1202404-23-6 | Molecular Weight | 330.81 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19ClO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Neuroinflammatory-IN-3Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1][2]. |
| Name | Neuroinflammatory-IN-3 |
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| Description | Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1][2]. |
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| Related Catalog | |
| In Vitro | Neuroinflammatory-IN-3（compound 1）在 10μM 浓度下抑制 BV-2 小胶质细胞中 LPS 介导的 NO 释放至 70%，IC50 为 5.22μM。Neuroinflammatory-IN-3 与微管蛋白的秋水仙碱结合域结合[1]。 Neuroinflammatory-IN-3（compound 1；72 小时）对 HeLa、U266、A549 和 MCF7 细胞系具有抗增殖作用，IC50 分别值为 450 nM、416 nM、381 nM 和 744 nM[2]。 Neuroinflammatory-IN-3（compound 1；1 μM；3-12 小时）以时间依赖性方式触发细胞周期停滞[2]。 Neuroinflammatory-IN-3（compound 1）以剂量依赖性方式抑制微管蛋白聚合[2]。 Cell Cycle Analysis[2] Cell Line: HeLa cells Concentration: 1 μM Incubation Time: 3 h, 6 h, 12 h Result: Triggered cell-cycle arrest. |
| References |
| Molecular Formula | C19H19ClO3 |
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| Molecular Weight | 330.81 |