2121591-52-2

2121591-52-2 structure

Name: Nampt-IN-3
Chemical Name: Nampt-IN-3
CAS Number: 2121591-52-2
Molecular Formula: C₂₉H₂₅N₇O₂
Molecular Weight: 503.55
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-08-04 15:18:58
Modify Date: 2025-08-27 19:16:34
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].

Name	Nampt-IN-3

Description	Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.

Molecular Formula	C₂₉H₂₅N₇O₂
Molecular Weight	503.55