2361384-14-5
2361384-14-5 structure
- Name: Neuroinflammatory-IN-2
- Chemical Name: Neuroinflammatory-IN-2
- CAS Number: 2361384-14-5
- Molecular Formula: C25H27FN2O3
- Molecular Weight: 422.49
- Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
- Create Date: 2022-08-22 16:12:14
- Modify Date: 2024-01-16 14:30:50
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Neuroinflammatory-IN-2 (compound 7i) is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].
| Name | Neuroinflammatory-IN-2 |
|---|
| Description | Neuroinflammatory-IN-2 (compound 7i) is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1]. |
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| Related Catalog | |
| Target |
MAO-B:10.30 μM (IC50) |
| In Vitro | Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H2O2-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively[1]. Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively[1]. |
| References |
| Molecular Formula | C25H27FN2O3 |
|---|---|
| Molecular Weight | 422.49 |