Bioorganic & Medicinal Chemistry 2008-04-01

Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.

Eui Seok Shin, Jiyoung Park, Jae-Min Shin, Dooho Cho, Si Young Cho, Dong Wook Shin, Mira Ham, Jae Bum Kim, Tae Ryong Lee

Index: Bioorg. Med. Chem. 16 , 3580-6, (2008)

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Abstract

Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP(+)-competitive inhibitors of G6PD and other enzymes that employ NADP(+) as a coenzyme, such as IDH and 6PGD.