Epicatechin

Modify Date: 2024-01-02 19:59:17

Epicatechin structure	Common Name	Epicatechin
	CAS Number	490-46-0	Molecular Weight	290.268
	Density	1.6±0.1 g/cm3	Boiling Point	630.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄O₆	Melting Point	240 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	335.0±31.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Epicatechin

(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Name	(-)-epicatechin
Synonym	More Synonyms

Description	(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
Related Catalog	Natural Products >> Flavonoids Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	COX-1:3.2 μM (IC50)
In Vitro	(-)-Epicatechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM[1]. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. In RINm5F cells, (-)-Epicatechin is shown to block the inhibition of insulin release after addition of IL-1β. Additionally, (-)-Epicatechin is shown to inhibit the proliferation of Hodgkin's lymphoma cells and Jurkat T cells, which is attributed to the ability of (-)-Epicatechin to inhibit the binding of NF-κB to DNA in these cells. In human colorectal cancer HCT-116 cells, combining 20 μM Panaxadiol with 150, 200, or 250 μM (-)-Epicatechin results in growth inhibition of 51%, 97%, and 95%, respectively. The combination also increases the apoptosis level by 11.9%, 16.6%, and 25.8%, as examined by annexin V/PI staining[2].
In Vivo	Animals receive 1 mg/kg of (-)-Epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups undergo 15 days of treadmill exercise. Significant increases in treadmill performance (~50%) and enhanced in situ muscle fatigue resistance (~30%) are observed with (-)-Epicatechin[3].
Animal Admin	Mice[3] 1-year-old, male C57BL/6N mice (n=25) are randomized into four groups. Mice in the (-)-Epicatechin groups 3 and 4 are given 1.0 mg/kg twice a day (morning and evening) for 15 consecutive days, whereas animals in the control groups 1 and 2 receive the vehicle (water). Both (-)-Epicatechin and vehicle are administered via oral gavage[3].
References	[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. [3]. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31.

Density	1.6±0.1 g/cm3
Boiling Point	630.4±55.0 °C at 760 mmHg
Melting Point	240 °C (dec.)(lit.)
Molecular Formula	C₁₅H₁₄O₆
Molecular Weight	290.268
Flash Point	335.0±31.5 °C
Exact Mass	290.079041
PSA	110.38000
LogP	0.49
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.742
Storage condition	2-8°C

Epicatechin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KB3745000

CHEMICAL NAME :: Epicatechol, (-)-

CAS REGISTRY NUMBER :: 490-46-0

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H14-O6

MOLECULAR WEIGHT :: 290.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KB3745000

Precursor 8
CAS#:87292-49-7 tetrabeuzyl-(-)... CAS#:29106-51-2 Procyanidol B4 CAS#:989-51-5 (-)-Epigallocat... CAS#:154-23-4 Catechin
CAS#:117-39-5 Quercetin CAS#:13157-90-9 2-[3,4-bis(phen... CAS#:1392108-91-6 3,5,7-tris(benz... CAS#:20315-25-7 Procyanidin B1
DownStream 9
CAS#:1707-75-1 1,1-DIPHENYL-2-... CAS#:621-54-5 3-(3-Hydroxyphe... CAS#:31129-94-9 5-(3,4-dihydrox... CAS#:111397-00-3 2-[(2S)-3-(3,4-...
CAS#:191666-22-5 2(3H)-Furanone,... CAS#:979-92-0 SAH CAS#:29106-49-8 ProcyanidinB2 CAS#:12798-57-1 Procyanidin B5
CAS#:4670-05-7 Theaflavin

Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: responses of major antioxidant enzymes and the Nrf2 rescue pathway.

Toxicol. Appl. Pharmacol. 283(1) , 65-74, (2015)

(-)-Epigallocatechin-3-gallate (EGCG), a constituent of green tea, has been suggested to have numerous health-promoting effects. On the other hand, high-dose EGCG is able to evoke hepatotoxicity. In t...

Identification of Vitis vinifera L. grape berry skin color mutants and polyphenolic profile.

Food Chem. 194 , 117-27, (2015)

A germplasm set of twenty-five grapevine accessions, forming eleven groups of possible berry skin color mutants, were genotyped with twelve microsatellite loci, being eleven of them identified as true...

Bi-layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application: in-vitro and in-vivo studies.

J. Biomed. Nanotechnol. 9(9) , 1495-508, (2013)

Present investigation involves the development of a bi-layer dressing of gelatin nanofibrous mat loaded with epigallocatechin gallate (EGCG)/poly vinyl alcohol (PVA) hydrogel and its in-vivo evaluatio...

(2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol

(-)-3 3' 4' 5 7-Pentahydroxyflavan

(-)-epicatechin

(−)-Epicatechin,from green tea

(-)Epicatechin

(2R,3R)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol

2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3R)-

L-Epicatechin

MFCD00075648

(−)-cis-3,3',4',5,7-Pentahydroxyflavane

(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol

epicatechin

EINECS 207-710-1

BioBioPha
China
Product Name: Epicatechin
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Epicatechin
Price: ￥338.0/20mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: L-Epicatechin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-Epicatechin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: L-Epicatechin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (-)-epicatechin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Epicatechin suppliers

Price: ￥343.2/250mg

Reference only. check more Epicatechin price

Epicatechin

Use of Epicatechin

Names

Epicatechin Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles187

Synonyms