Procyanidin B1

Modify Date: 2024-01-02 10:03:15

Procyanidin B1 structure	Common Name	Procyanidin B1
	CAS Number	20315-25-7	Molecular Weight	578.520
	Density	1.7±0.1 g/cm3	Boiling Point	955.3±65.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₂₆O₁₂	Melting Point	231～232℃
	MSDS	USA	Flash Point	531.6±34.3 °C

Use of Procyanidin B1

Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

Name	procyanidin b1
Synonym	More Synonyms

Description	Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology
In Vitro	Procyanidin B1 is a polyphenolic flavonoid isolated from fruits and fruit juices, binds to TLR4/MD-2 complex, and has anti-inflammatory activity. Procyanidin B1 causes cellular toxicity at concentrations >100 μg/mL. Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells[1]. Procyanidin B1 (50-100 µM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 µM, caspase-8 at concentrations of 30, 50, and 100 µM and caspase-9 at concentrations of 10, 30, 50, and 100 µM[2]. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα[3].
Cell Assay	To investigate the cytotoxic effect of Procyanidin B1, viability of THP1 cells is assessed using CCK8 assay. THP1 cells are treated with Procyanidin B1 for 18 h, and 10 μL of CCK8 solution is then added to each well and the cultures are incubated for 4 h at 37°C. The optical density (OD) at 450 nm is measured using an ELx808 Absorbance Microplate Reader. The Procyanidin B1 concentration tested ranges from 50 to 200 μg/mL. Each sample is tested in triplicate[1].
References	[1]. Xing J, et al. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling. Mol Cell Biochem. 2015 Sep;407(1-2):89-95. [2]. Kanno H, et al. Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid β oligomer-induced neuronal death. J Ethnopharmacol. 2015 Jan 15;159:122-8. [3]. Shimada T, et al. Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. Eur J Pharmacol. 2012 Feb 29;677(1-3):147-53.

Density	1.7±0.1 g/cm3
Boiling Point	955.3±65.0 °C at 760 mmHg
Melting Point	231～232℃
Molecular Formula	C₃₀H₂₆O₁₂
Molecular Weight	578.520
Flash Point	531.6±34.3 °C
Exact Mass	578.142456
PSA	220.76000
LogP	0.30
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.803
Storage condition	2-8°C

Procyanidin B1 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	24/25
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29329990

Precursor 6
CAS#:664351-43-3 procyanidin B1 ... CAS#:154-23-4 Catechin CAS#:20728-73-8 (2R-trans)-2-[3... CAS#:87292-49-7 tetrabeuzyl-(-)...
CAS#:490-46-0 Epicatechin CAS#:664351-42-2 [4,8]-2,3-cis-3...
DownStream 4
CAS#:490-46-0 Epicatechin CAS#:154-23-4 Catechin CAS#:128837-34-3 4α-Benzylthioep... CAS#:13306-05-3 cyanidin

Effects of UV exclusion on the physiology and phenolic composition of leaves and berries of Vitis vinifera cv. Graciano.

J. Sci. Food Agric. 95(2) , 409-16, (2014)

Ultraviolet (UV) radiation induces adaptive responses that can be used for plant production improvement. The aim of this study was to assess the effect of solar UV exclusion on the physiology and phen...

UHPLC-PDA-ESI/HRMSn profiling method to identify and quantify oligomeric proanthocyanidins in plant products.

J. Agric. Food Chem. 62(39) , 9387-400, (2014)

Oligomeric proanthocyanidins were successfully identified by UHPLC-PDA-HRMS(n) in a selection of plant-derived materials (jujube fruit, Fuji apple, fruit pericarps of litchi and mangosteen, dark choco...

Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Bioorg. Med. Chem. 18 , 28-35, (2010)

The applicability of the newly developed RM1 and PM6 methods implemented in the semiempirical quantum chemistry mopac2009 software package in modeling free radical scavenging activity of flavonoids wa...

Proanthocyanidin B2

(2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol

Proanthocyanidin B1

4,8"-Bi-[(+)-epicatechin]

PROCYANIDINDIMERB2

ProcyanidinB1

[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'S,4R)-

Procyanidin B1

Procyanidol B2

Procyanidin B2

Proanthocyanidin

UNII-L88HKE854X

(2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol

[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Procyanidin B1
Price: ￥1318.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Procyanidin B1
Price: $380.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $993/10mM*1mLinDMSO

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Procyanidin B1

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