(-)-Gallocatechin gallate
(-)-Gallocatechin gallate structure
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Common Name | (-)-Gallocatechin gallate | ||
|---|---|---|---|---|
| CAS Number | 4233-96-9 | Molecular Weight | 458.372 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 909.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H18O11 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 320.0±27.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.
Food Chem. 173 , 607-18, (2014) A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performance liquid chromatography coupled to single-stage Orbitrap hi... |
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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
J. Nat. Prod. 73 , 1193-5, (2010) Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of esta... |
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Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease.
Electrophoresis 36 , 2002-16, (2015) Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats f... |
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Development and validation of UHPLC-MS/MS method for determination of eight naturally occurring catechin derivatives in various tea samples and the role of matrix effects.
J. Pharm. Biomed. Anal. 114 , 62-70, (2015) A complete analytical procedure combining optimized tea infusion preparation and validated UHPLC-MS/MS method was developed for routine quantification of eight naturally occurring catechin derivatives in various tea samples. The preparation of tea infusions w... |
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Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.
Bioorg. Med. Chem. 16 , 3580-6, (2008) Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inh... |
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New inhibitors for expression of IgE receptor on human mast cell.
Bioorg. Med. Chem. Lett. 20 , 2299-302, (2010) Exploration for inhibitors against expression of IgE receptor (Fc epsilonRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active ... |
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Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.
J. Nat. Prod. 68 , 1386-9, (2005) Biologically active compounds from several useful plants were enriched using foam fractionation, a separatory method belonging to the adsorptive bubble separation (ABS). Nonpolar humulones (1-6) from Pilsener beer, curcuminoids (7-9) from turmeric, and carote... |
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Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
J. Med. Chem. 52 , 6543-5, (2009) Most cancer deaths result from spread of the primary tumor to distant sites (metastasis). MET is an important protein for metastasis in multiple tumor types. Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells... |
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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
J. Med. Chem. 49 , 3345-53, (2006) After the discovery of a potent natural flavonoid glucoside as a potent inhibitor of FabI, a large flavonoid library was screened against three important enzymes (i.e., FabG, FabZ, and FabI) involved in the fatty acid biosynthesis of P. falciparum. Although f... |
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Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus.
Antimicrob. Agents Chemother. 52 , 962-70, (2008) In the absence of a fully effective herpes simplex virus (HSV) vaccine, topical microbicides represent an important strategy for preventing HSV transmission. (-)-Epigallocatechin gallate (EGCG) (molecular weight, 458.4) is the primary catechin in green tea. T... |