DUBs-IN-1
Modify Date: 2024-01-14 11:22:52
DUBs-IN-1 structure
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Common Name | DUBs-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 924296-18-4 | Molecular Weight | 337.33400 | |
| Density | 1.32g/cm3 | Boiling Point | 632.2ºC at 760 mmHg | |
| Molecular Formula | C20H11N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 336.2ºC | |
Use of DUBs-IN-1DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8. |
| Name | 9-[(Benzyloxy)imino]-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
|---|---|
| Synonym | More Synonyms |
| Description | DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.24 μM (USP8)[1] |
| In Vitro | DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1]. |
| References |
| Density | 1.32g/cm3 |
|---|---|
| Boiling Point | 632.2ºC at 760 mmHg |
| Molecular Formula | C20H11N5O |
| Molecular Weight | 337.33400 |
| Flash Point | 336.2ºC |
| Exact Mass | 337.09600 |
| PSA | 94.95000 |
| LogP | 3.16956 |
| Index of Refraction | 1.704 |
| DUBs-IN-1 |