2055990-90-2

2055990-90-2 structure

Name: GRK2-IN-1
Chemical Name: GRK2-IN-1
CAS Number: 2055990-90-2
Molecular Formula: C₂₄H₂₅FN₄O₄
Molecular Weight: 452.48
Catalog: Research Areas Cardiovascular Disease
Create Date: 2019-10-07 20:15:52
Modify Date: 2024-01-29 18:48:33
GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].

Name	GRK2-IN-1

Description	GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	GRK2:30 nM (IC50) GRK5:7.1 μM (IC50)
References	[1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.

Molecular Formula	C₂₄H₂₅FN₄O₄
Molecular Weight	452.48