GRK2-IN-1

Modify Date: 2024-01-29 18:48:33

GRK2-IN-1 structure	Common Name	GRK2-IN-1
	CAS Number	2055990-90-2	Molecular Weight	452.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₅FN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GRK2-IN-1

GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].

Name	GRK2-IN-1

Description	GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	GRK2:30 nM (IC50) GRK5:7.1 μM (IC50)
References	[1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.

Molecular Formula	C₂₄H₂₅FN₄O₄
Molecular Weight	452.48

GRK2-IN-1

Use of GRK2-IN-1

Names

GRK2-IN-1 Biological Activity

Chemical & Physical Properties