1941168-71-3
1941168-71-3 structure
- Name: GRK2-IN-115h hydrochloride
- Chemical Name: GRK2-IN-115h hydrochloride
- CAS Number: 1941168-71-3
- Molecular Formula: C24H22ClF3N6O
- Molecular Weight: 502.926
- Create Date: 2020-01-12 10:28:33
- Modify Date: 2023-01-17 19:27:33
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A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment.
| Name | GRK2-IN-115h hydrochloride |
|---|
| Description | A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment. |
|---|---|
| References | References 1. Okawa T, et al. J Med Chem. 2017 Aug 24;60(16):6942-6990. View Related Products by Target GRK (GPCRK) |
| Molecular Formula | C24H22ClF3N6O |
|---|---|
| Molecular Weight | 502.926 |