1303470-48-5

1303470-48-5 structure

Name: KHK-IN-1 hydrochloride
Chemical Name: KHK-IN-1 hydrochloride
CAS Number: 1303470-48-5
Molecular Formula: C₂₁H₂₇ClN₈S
Molecular Weight: 459.011
Catalog: Research Areas Others
Create Date: 2018-02-07 19:58:12
Modify Date: 2024-01-16 20:50:57
KHK-IN-1 Hcl is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK.

Name	KHK-IN-1 hydrochloride
Synonyms	Pyrimido[5,4-d]pyrimidine-4,8-diamine, N8-(cyclopropylmethyl)-N4-[2-(methylthio)phenyl]-2-(1-piperazinyl)-, hydrochloride (1:1) N8-(Cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(1-piperazinyl)pyrimido[5,4-d]pyrimidine-4,8-diamine hydrochloride (1:1) KHK-IN-1 (hydrochloride)

Description	KHK-IN-1 Hcl is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. [2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.