924296-19-5

924296-19-5 structure

Name: DUBs-IN-2
Chemical Name: 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)
CAS Number: 924296-19-5
Molecular Formula: C₁₅H₉N₅O
Molecular Weight: 275.26500
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2017-03-25 22:54:42
Modify Date: 2024-01-12 10:11:36
DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

Name	9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)
Synonyms	9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile DUBs-IN-2

Description	DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase Research Areas >> Cancer
Target	IC50: 0.28 μM (USP8)[1]
In Vitro	DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].
References	[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.