DUBs-IN-2
Modify Date: 2025-08-25 12:18:39
DUBs-IN-2 structure
|
Common Name | DUBs-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 924296-19-5 | Molecular Weight | 275.26500 | |
| Density | 1.36±0.1 g/cm3 (20 °C, 760 mmHg) | Boiling Point | 555.7±60.0 °C (760 mmHg) | |
| Molecular Formula | C15H9N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DUBs-IN-2DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. |
| Name | 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino) |
|---|---|
| Synonym | More Synonyms |
| Description | DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.28 μM (USP8)[1] |
| In Vitro | DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1]. |
| References |
| Density | 1.36±0.1 g/cm3 (20 °C, 760 mmHg) |
|---|---|
| Boiling Point | 555.7±60.0 °C (760 mmHg) |
| Molecular Formula | C15H9N5O |
| Molecular Weight | 275.26500 |
| Exact Mass | 275.08100 |
| PSA | 94.95000 |
| LogP | 1.98926 |
| InChIKey | VKVAJBRQGBRHIK-ZHZULCJRSA-N |
| SMILES | CCON=C1c2ccccc2-c2nc(C#N)c(C#N)nc21 |
| 9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| DUBs-IN-2 |