Thiol-PEG8-alcohol

Modify Date: 2024-01-10 12:05:48

Thiol-PEG8-alcohol Structure
Thiol-PEG8-alcohol structure
Common Name Thiol-PEG8-alcohol
CAS Number 791620-96-7 Molecular Weight 386.50100
Density N/A Boiling Point N/A
Molecular Formula C16H34O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiol-PEG8-alcohol


Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Thiol-PEG8-alcohol Biological Activity

Description Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C16H34O8S
Molecular Weight 386.50100
Exact Mass 386.19700
PSA 123.64000
LogP 0.02470

 Synonyms

3,6,9,12,15,18,21-Heptaoxatricosan-1-ol,23-mercapto
Thiol-PEG8-alcohol