Thiol-PEG8-alcohol

Names

[ CAS No. ]:
791620-96-7

[ Name ]:
Thiol-PEG8-alcohol

[Synonym ]:
3,6,9,12,15,18,21-Heptaoxatricosan-1-ol,23-mercapto
Thiol-PEG8-alcohol

Biological Activity

[Description]:

Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₃₄O₈S

[ Molecular Weight ]:
386.50100

[ Exact Mass ]:
386.19700

[ PSA ]:
123.64000

[ LogP ]:
0.02470

Thiol-PEG8-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds