Benzyl-PEG8-alcohol

Names

[ CAS No. ]:
477775-73-8

[ Name ]:
Benzyl-PEG8-alcohol

[Synonym ]:
1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol
octaethylene glycol monobenzyl ether

Biological Activity

[Description]:

Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₄₀O₉

[ Molecular Weight ]:
460.55800

[ Exact Mass ]:
460.26700

[ PSA ]:
94.07000

[ LogP ]:
1.31170

Benzyl-PEG8-alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds