Tr-PEG4-OH

Names

[ Name ]:
Tr-PEG4-OH

[Synonym ]:
2-(2-(2-(2-(trityloxy)ethoxy)ethoxy)ethoxy)ethanol
2,5,8,11-Tetraoxatridecan-13-ol,1,1,1-triphenyl
13,13,13-triphenyl-3,6,9,12-tetraoxatridecan-1-ol
Tr-PEG5
11-(triphenylmethyloxy)-3,6,9-trioxaundecan-1-ol
1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol
13,13,13-triphenyl-3,6,9,12-tetraoxatridecanol
tetraethylene glycol monotrityl ether
TrtO-4eg-OH

Biological Activity

[Description]:

Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Zhang Q, et al. Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives. J Org Chem. 2014 Oct 17;79(20):9546-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₂O₅

[ Molecular Weight ]:
436.54000

[ Exact Mass ]:
436.22500

[ PSA ]:
57.15000

[ LogP ]:
4.03720

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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