Mal-PEG4-OH

Names

[ CAS No. ]:
1421933-37-0

[ Name ]:
Mal-PEG4-OH

[Synonym ]:
1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-

Biological Activity

[Description]:

Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
427.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₉NO₆

[ Molecular Weight ]:
273.282

[ Flash Point ]:
212.6±25.9 °C

[ Exact Mass ]:
273.121246

[ LogP ]:
-1.61

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.512

Mal-PEG4-OH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds