Thiol-PEG5-alcohol

Modify Date: 2024-09-15 10:09:57

Thiol-PEG5-alcohol Structure
Thiol-PEG5-alcohol structure
Common Name Thiol-PEG5-alcohol
CAS Number 248582-03-8 Molecular Weight 254.341
Density N/A Boiling Point N/A
Molecular Formula C10H22O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiol-PEG5-alcohol


Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Thiol-PEG5-alcohol
Synonym More Synonyms

 Thiol-PEG5-alcohol Biological Activity

Description Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C10H22O5S
Molecular Weight 254.341

 Synonyms

2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethanol
HS-PEG5-OH
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