1,1,1-Trifluoroethyl-PEG4-alcohol

Modify Date: 2024-01-09 21:59:09

1,1,1-Trifluoroethyl-PEG4-alcohol Structure
1,1,1-Trifluoroethyl-PEG4-alcohol structure
Common Name 1,1,1-Trifluoroethyl-PEG4-alcohol
CAS Number 1807512-41-9 Molecular Weight 276.250
Density 1.2±0.1 g/cm3 Boiling Point 324.8±37.0 °C at 760 mmHg
Molecular Formula C10H19F3O5 Melting Point N/A
MSDS N/A Flash Point 152.6±23.0 °C

 Use of 1,1,1-Trifluoroethyl-PEG4-alcohol


1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1,1,1-Trifluoroethyl-PEG5-Alcohol
Synonym More Synonyms

 1,1,1-Trifluoroethyl-PEG4-alcohol Biological Activity

Description 1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 324.8±37.0 °C at 760 mmHg
Molecular Formula C10H19F3O5
Molecular Weight 276.250
Flash Point 152.6±23.0 °C
Exact Mass 276.118469
LogP -1.10
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.407

 Synonyms

3,6,9,12-Tetraoxatetradecan-1-ol, 14,14,14-trifluoro-
MFCD28950755
14,14,14-Trifluoro-3,6,9,12-tetraoxatetradecan-1-ol