Azido-PEG5-alcohol

Modify Date: 2025-08-20 12:34:32

Azido-PEG5-alcohol structure	Common Name	Azido-PEG5-alcohol
	CAS Number	86770-68-5	Molecular Weight	263.291
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₂₁N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	100 °C

Use of Azido-PEG5-alcohol

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	14-Azido-3,6,9,12-tetraoxatetradecanol
Synonym	More Synonyms

Description	Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20. [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.

Molecular Formula	C₁₀H₂₁N₃O₅
Molecular Weight	263.291
Flash Point	100 °C
Exact Mass	263.148132
PSA	106.90000
LogP	-1.59
Index of Refraction	1.47

Azido-PEG5-alcohol MSDS(Chinese)

3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido-

14-Azido-3,6,9,12-tetraoxatetradecan-1-ol

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

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China
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China
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